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Tohoku Univ. Technology : 13C Immobilized Reagent : T23-086

Novel liquid reagent which is easy to handle and to control the reaction equivalent

Carboxylic acid compounds containing aromatic rings are important molecular structures as bioactive compounds and their precursors. For example, aromatic carboxylic acids such as aspirin and telmisartan and aromatic ring-containing carboxylic acids such as atorvastatin are known as important drugs. Therefore, it is desired to develop carboxylation reactions of organic molecules that can efficiently synthesize aromatic carboxylic acid compounds. On the other hand, introduction of the 12C isotope 13C into organic molecules is important for elucidating the mechanism of chemical reactions or monitoring in vivo. For the conventional method, 13CO2 gas is reacted as the 13C source, but special equipment and technology are required, and thus it is difficult to accurately control the amount of the gas. This invention provides to a novel 13C immobilizer in a liquid form that is easy to handle.

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Heavy water (D2O) "synthesis, analysis, and characterization" is a stable isotope of hydrogen (H) atom.

Active in pharmaceutical raw materials, NMR heavy solvents, nuclear power plant moderators, research reagents, organic synthesis, organic analysis, and more.

Heavy water (D2O) is a molecule in which the isotope deuterium (D) atom is bonded to an oxygen (O) atom instead of a hydrogen (H) atom. Deuterium contains a neutron that hydrogen does not have, resulting in an increased mass and different physical properties. Heavy water is used as a raw material in pharmaceuticals and as a tracer. Deuterium can be incorporated into drug molecules as a substitute for hydrogen, improving the stability and duration of the drug's effects. Additionally, it is used as a moderator in nuclear power generation. When neutrons collide with deuterium, they lose energy more than when they collide with hydrogen, making nuclear fission reactions more likely. Therefore, heavy water is an essential substance for enhancing the efficiency of nuclear reactors. It is also used as a heavy solvent for NMR. [Features] - Deuterium (D) atoms, an isotope, bond with oxygen atoms instead of hydrogen (H) atoms. - Deuterium contains a neutron that hydrogen does not have. - Increased mass results in different physical properties. *For more details, please refer to the PDF document or feel free to contact us.

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